Cell Therapy And Hematologic Oncology

Cancers Of The Bone Marrow, Blood, And Lymphatic System Such As Leukemias, Myeloproliferative Syndromes, Lymphoproliferative Syndromes, And Myelomas Are Studied, Diagnosed, And Treated In Onco-Hematology.

Hematologists Are Doctors Who Study Blood Cells And The Processes That Lead To The Formation Of Those Cells. They Focus On The Pathogenesis Of These Cancer-Causing Cells, Sometimes Over The Course Of A Long Period Of Time, In Order To Come Up With A Treatment Option That Is Effective. For The Former Poitou-Charentes Region, The Haematology And Cell Therapy Service Is Organised Around National And International Experts In Each Of The Fields And Pathologies That Are Addressed By This Specialty And Provides A Resource For Each Of These Diseases. Each And Every One Of The Former Poitou-Charentes Region’s Patients Who Is Treated For A Pathology Is Subject To An Opinion Or Even Treatment By The Haematology And Cell Therapy Service Of Poitiers University Hospital.

There Are Three Types Of Research That Go Into Providing Patient Care: Fundamental, Translational, And Clinical. Patients Are Treated In Therapeutic Trials For A Large Number Of Diseases, Which Gives Them Early Access To New Drugs And New Ideas In Haematology.

Hematological Diseases Can Be Treated In A Variety Of Ways, Some Of Which Can Be Used Alone Or In Combination:

  • Chemotherapy
  • Radiotherapy
  • Targeted Therapies
  • Immunotherapy



Cancer Cells Can Be Destroyed Or Prevented From Multiplying Through Chemotherapy, Which Administers Drugs To The Patient In An Effort To Combat Cancer.


Chemotherapy Drugs Come In A Wide Variety And Are Frequently Used In Combination To Maximise Their Effectiveness. They Can Be Administered Intravenously, Intramuscularly, Or Orally As Tablets.

However, Chemotherapy Drugs Can Also Cause Harm To Healthy, Rapidly Dividing Cells. These Effects Can Include Nausea, Vomiting, Hair Loss, And Fatigue In Addition To Cancer Cell Destruction. Depending On The Medication And The Patient’s Tolerance, These Side Effects Can Last Anywhere From A Few Minutes To Several Days.



Radiation Therapy Is A Cancer Treatment That Focuses On A Specific Area Of The Body. Cancer Cells Are Destroyed By Blocking Their Ability To Multiply Using Radiation (Also Known As Rays Or Radiation).


In An Allograft Setting, Total Body Irradiation (Tbi) Radiation Therapy Destroys The Patient’s Bone Marrow And Immune System To Aid Engraftment. It Is Always Used In Conjunction With Chemotherapy To Maximise The Effectiveness Of Both Treatments.

Targeted Therapies

By Interfering With Cancer Cells’ Molecular Alterations Or The Mechanisms That Lead To Their Development And Spread, Targeted Therapies Aim To Slow Or Stop Their Growth Or Spread.



Cancer Immunotherapy: A Promising New Treatment Option

To Aid The Immune System In The Fight Against Cancer, Immunotherapy Is A Treatment Option. To Keep You Healthy And Fight Off Infections And Disease, Your Immune System Works Hard. The Lymphatic System Is Made Up Of White Blood Cells, Organs, And Tissues.

Biological Therapy Includes Immunotherapy. Biotherapy Is A Treatment Method That Targets Cancer By Using Substances Produced By Living Organisms.


Immunotherapy Comes In A Variety Of Forms:

Antibodies Made From A Specific Type Of Antibody Called A Monoclon

Certain Specific Mechanisms In Cancer Cells Can Be Identified And Blocked, Or The Cancer Cell Itself Can Be Identified And Destroyed.


Cancer Cells Have Been Known To Put The Immune System To Sleep By Putting Pressure On The System’s Built-In Brakes To Slow Them Down. They Are Also Capable Of Rerouting The Body’s Defences So That Tumour Growth Is Favoured. By Removing These Inhibitory And Diverting Mechanisms, Immunomodulators Seek To Restore The Immune System’s Functionality. Certain Cancers And Haematology In Hodgkin Lymphoma Have Already Seen The Use Of Anti-Pd-1, Anti-Pd-L1, And Anti-Ctla-4 Molecules With Different Mechanisms Of Action.

Cell Therapy Is An Option.

When It Comes To Biotherapy, Living Organisms (Such As Yeasts, Ferments, And Certain Microbes) Or Substances Derived From Living Organisms Are Used As Therapeutic Agents (Hormones, Organ Or Tissue Extracts). In Contrast To Chemotherapy, Which Makes Use Of Man-Made Chemicals. “Biotherapies” Include Cell Therapy, Which Uses Cells Derived From Embryonic Stem Cells (Also Known As Undifferentiated Cells) To Treat An Organ Or An Organism By Substituting Or Replacing Defective Cells.


Hematopoietic Stem Cells Are Removed From The Patient’s Blood And Stored (By Freezing) As An Autograft. After An Intensive Chemotherapy Treatment To Shorten The Duration Of Aplasia, These Cells Are Reinjected.

When Immunochemotherapy Treatments Fail To Cure A Patient, Doctors May Consider An Allogeneic Transplant. In This Procedure, Hematopoietic Stem Cells From An Hla-Compatible Donor Are Administered After Chemotherapy And Radiotherapy Have Destroyed The Patient’s Bone Marrow And Immune System To Create New Bone Marrow And Immune Cells. Donors May Come From A Donor Registry Or A Family Tree (Anonymous Donation). Immune Cells (T Lymphocytes) That Have Been Manipulated In The Laboratory To Be Active Against Cancer Cells Are Injected Into The Patient As Car-T Cells. Personalized Medical Techniques Are Needed For The Car-T Cell Transplant, Which Is Currently Undergoing Clinical Trials At The Hospital.

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